The B3PP-Pred Web Server is the result of a scientific partnership between three universities: the Federal University of Pará (Brazil), the Federal University of the Westen Pará (Brazil), and the University of Ghent (Belgium). The peptide dataset applied in the development of the algorithm was obtained from the peptide library available in the BrainPeps database.

The Web Server is an integrated toolkit for sequence and structure analysis of blood-brain barrier penetrating peptides (B3PPs). This tool is composed of three independent module analyses of peptides: Sequence Analysis Module, Structure Analysis Module, and the B3PP Prediction Module (B3PP-Pred Algorithm).

The machine learning model behind the B3PPs prediction is composed of a supervised manifold dimensionality reduction algorithm and XGBoost regressor and classifier.